Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori B. Ma, J. Ma, D. Liu, L. Guo, H. Chen, J. Ding, W. Liu, H. Zhang* Oncotarget, 7 (2016) 40965-40977. DNA N6-methyladenine modification plays an important role in regulating a variety of biological functions in bacteria. However, the mechanis...
Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells Kong J, Du J, Wang Y, Yang M, Gao J, Wei X, Fang W*, Zhan J*, Zhang H* Oncotarget. 2016 Oct 20. doi: 10.18632/oncotarget.12779. Kindlin-1, an integrin-interacting protein, has been implicated ...
PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6 J. Wan, W. Xu, J. Zhan, J. Ma, X. Li, Y. Xie, J. Wang, W.G. Zhu, J. Luo, H. Zhang*Nucleic acids research, (2016). 研究首次发现了HOXB9可以被乙酰化酶PCAF催化发生乙酰化修饰,同时可以被去乙酰化酶SIRT1催化发生去乙酰化。PCAF可...
Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix. Fu Chak Ho, Wei Zhang, Yuk Yin Li, Barbara Pui Chan Department of Mechanical Engineering,Haking Wong Building, Pokfulam Road, The University of Hong Kong, Hong Kong Special Administrative Region. Abstract Cells are known to respond to mu...
ADAMTS7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z*, Kong W*.Circulation. 2015;131(13):1191-201. ADAMTS-7, a member of the disintegrin and metalloproteinase wi...
Kindlin-2 controls TGF-b signalling and Sox9 expression to regulate chondrogenesis Wu, C., Jiao, H., Lai, Y., Zheng, W., Chen, K., Qu, H., Deng, W., Song, P., Zhu, K., Cao, H., Galson, D.L., Fan, J., Im, H.J., Liu, Y., Chen, J., Chen, D., Xiao, G.. Nature Communications. 2015;6:7531. Abstract The signals that control skeletogenesis are incompletely understood. Here we show that deleting Kind...
Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing Sun H, Liu J, Zheng YJ, Pan YD, Zhang K, Chen JF*. . Dev Cell. 2014;30(1):61-70. (Cover Story, *Corresponding author) State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese;Academy of Sciences, Shangh...
Matricellular protein periostin contributes to hepatic inflammation and fibrosis Huang Y, Liu W, Xiao H, Maitikabili A, Lin Q, Wu T, Huang Z, Liu F, Luo Q, Ouyang G*. Am J Pathol. 2015;185:786-797. (*Corresponding author) State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China. Abstract Perio...
BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5 Junying Qin, Zhongmei Zhou, Wenlin Chen, Chunyan Wang, Hailin Zhang, GuangzheGe, Ming Shao, Dingyun You, Zhixiang Fan, Houjun Xia, Rong Liu, Ceshi Chen*. Nature Communications. 2015;6:8471. (*Corresponding author) Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences a...
Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR-338-3p-PKLR axis in hepatocellular carcinoma Nie H, Li J, Yang XM, Cao QZ, Feng MX, Xue F, Wei L, Qin W, Gu J, Xia Q, Zhang ZG*. 2015;62(4):1145-59. (*Corresponding author) the State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shangh...
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