邱晓彦,教授,博士生导师
 
北京大学基础医学院免疫学系副主任
卫生部医学免疫学重点实验室
    她的主要研究方向是“非免疫细胞来源的免疫球蛋白(Ig)结构及功能的研究”。Ig原本被定义为抗体分子,只能由B细胞产生。然而,邱晓彦等在国际上首次发现非B细胞可广泛产生Ig。他们的一系列重要发现表明,非B细胞产生的Ig主要发挥细胞生物学功能,如涉及细胞增殖及迁移,甚至肿瘤的发生及转移。该项成果也曾被评为2004年中国医药界十大新闻之一。目前该项创新性研究已经在国际专业杂志上发表20余篇文章。 
Xiaoyan Qiu,MD, Ph.D., Professor 
Department of Immunology, Peking University School of Basic Medical Science, 
Key Laboratory of Medical Immunology, Ministry of Health, Beijing, 100191, China
 
In the Qiu' laboratory, they are trying to understand that Molecular structure and function of non B cell-derived immunoglobulin (Ig). It has traditionally been believed that the production of immunoglobulin (Ig) is restricted to B lineage cells. However, Qiu et al for the first time in the field reported that Ig could be widely produced by different types of lineage cells. Increasing evidence from Qiu’lab suggested that non B cell-derived Ig mainly serve as cell biological function, which was involved in proliferation and migration of cell, even tumorigenesis and metastasis of cancer cells. The finding was chosen through public appraisal to be “Ten Flash-News of Progress of Science and Technology in Medical and Health field” in China at 2004. So far, they have published more 20 papers in the new field.
 
近两年代表性论著:
 
1. Chong Wang, Miaoran Xia, Xiaoping Sun, Zhiqiao He, Fanlei Hu, Lei Chen, Carlos E. Bueso-Ramos, Xiaoyan Qiu(并列责任作者) , C. Cameron Yin. IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration. Oncotarget. 2015 In press (IF 6.6)
2. Qinyuan Liao, Wei. Liu, Yang Liu, Fulin Wang, Chong Wang, Jingxuan Zhang, Ming Chu, Dongyang Jiang, Lin Xiao, Wenwei. Shao, Zhengzuo Sheng, Xia Tao, Lei Huo, C. Cameron Yin, Youhui Zhang, Gregory Lee, Jing Huang, Zihai Li, Xiaoyan. Qiu(责任作者). Aberrant High Expression of Immunoglobulin G in Epithelial Stem/Progenitor-like Cells Contributes to Tumor Initiation and Metastasis. Oncotarget. 2015 In press (IF 6.67)
3. Jingfang Liu, Miaoran Xia, Pingzhang Wang, Chong Wang, C. Cameron Yin, Xiaoyan Qiu(责任作者). Immunoglobulin gene expression in umbilical cord blood-derived CD34+ hematopoietic stem/progenitor cells. Gene. 2015 In press (IF 2.13)
4 Liu Y, Liu D, Wang C, Liao Q, Huang J, Jiang D, Shao W, Yin CC, Zhang Y, Lee G, Qiu X(责任作者). Binding of the monoclonal antibody RP215 to immunoglobulin G in metastatic lung adenocarcinomas is correlated with poor prognosis. Histopathology. 2015 Mar 9. (IF 2.33)
5. Jing Huang , Lin Xiao , Xiaoting Gong , Wenwei Shao , Yanhui Yin , Qinyuan Liao , Yang Meng , Yingmei Zhang , Dalong Ma , Xiaoyan Qiu(责任作者). Contribution of CCDC134, a Potential Cytokine, to CD8+ T Cell Effector Functions in Cancer Immunotherapy. CANCER RESEARCH, 2014,74(20):5734-45(IF 9.284) 
 
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