王子梅教授1998年毕业于中国协和医科大学北京协和医院内分泌专业,获医学博士学位。1999年起在北京大学基础医学院生物化学和分子生物学系工作,受聘讲师、副教授,曾担任系副主任主管教学,2006年赴香港大学李嘉诚医学院生物化学系工作,2009年加入深圳大学医学院生化教研室,2013年获广东省教授资格。2015年起任深圳大学医学部基础医学院副院长。
王子梅教授长期从事生物化学与分子生物学教学及衰老和抗衰老的分子机理研究,研究方向包括1. 正常衰老和早衰症发生的遗传与表观遗传学机理;2.抗衰老小分子化合物的筛选与应用;3.核基质微环境与DNA损伤修复、染色质高级结构的关系。目前主持2项国家自然科学基金面上项目和2项深圳市科技研发基金项目,参与多项包括国家自然科学基金重点项目在内的基金项目,并指导课题组成员获得国家自然科学基金青年基金项目资助。相关研究成果以SCI论文形式发表在PNAS、Aging cell、Cell Cycle等JCR 一二区国际期刊上,累计发表论文20余篇,论文被引总数180余次,多次参加国际国内学术会议交流并做口头报告。现为深圳市“抗衰老与再生医学”重点实验室核心成员,深圳市海外高层次“孔雀计划”B类人才,并担任国家自然科学基金同行评审专家,中国生物化学与分子生物学杂志审稿人,中国老年学会衰老与抗衰老科学委员会理事,中国生理学会基质委员会委员等职务。
论文代表作:
1. Liu J, Yin X, Liu B, Zheng H, Zhou G, Gong L, Li M, Li X, Wang Y, Hu J, Krishnan V, Zhou Z, Wang Z* HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells. Cell Cycle 2014,13(8), 1237 – 1247(*corresponding author)
2. Liu B#, Wang Z#, Ghosh S, Zhou Z. Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model. Aging Cell. 2013, 12(2):316-8. (#Co-first author)
3. Krishnan V#, Chow MZ#, Wang Z#, Zhang L#, Liu B, Liu X, Zhou Z. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2011, 108(30):12325-30. (#Co-first author)
4. Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun. 2013; 4:1868. 
5. Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab. 2012;16(6):738-50. 
 
Biography of Professor Zimei Wang
Professor Zimei Wang graduated from Department of Endocrinology, Peking Union Medical College Hospital with her doctoral degree in year 1998. She joined the department of Biochemistry and Molecular Biology, Basic Medical School of Peking University as a Lecturer in year 1999, and then became Associate Professor and Associate Dean responsible for teaching affairs of the department. She moved to Department of Biochemistry, Li Ka Shing Faculty of Medicine, Hong Kong University in 2006. After three years of research work, she joined the Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University in 2009 and got the professor certificate in 2013. She is currently serving as the Associate Dean of School of Basic Medical Science, Health Science Center, Shenzhen University. 
Professor Zimei Wang has a long record of commitment to education,she is also engaged in the research of Aging and anti-aging molecular mechanisms. Her research interests focus on the genetic and epigenetic mechanisms of aging and premature aging syndromes; anti-aging small molecular compounds screening and their applications; effect of nuclear matrix microenvironment on DNA damage repair and chromatin superstructure. These research projects are funded by several grants from National Natural Science Foundation of China and Shenzhen government organizations. Her studies appeared in JCR top or Q1 journals such as PNAS, Aging Cell, Cell Cycle etc. She has totally published more than 20 original papers and book chapters, the paper total cited frequency are being updated more than 180 times. She received the Shenzhen Overseas High-level Talent award in 2014 and is now a principal investigator in The Center for Anti-aging and Regenerative Medicine of Shenzhen City. She remains active on peer-review of NSFC projects and some academic journals including Chinese Journal of Biochemistry and Molecular Biology, she is also a member of Aging and Anti-aging Scientific Committee of Gerontological Society of China, and a member of Chinese Association for Physiological Sciences.
 
Selected publications:
1. Liu J, Yin X, Liu B, Zheng H, Zhou G, Gong L, Li M, Li X, Wang Y, Hu J, Krishnan V, Zhou Z, Wang Z* HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells. Cell Cycle 2014,13(8), 1237 – 1247(*Corresponding author)
2. Liu B#, Wang Z#, Ghosh S, Zhou Z. Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model. Aging Cell. 2013, 12(2):316-8. (#Co-first author)
3. Krishnan V#, Chow MZ#, Wang Z#, Zhang L#, Liu B, Liu X, Zhou Z. Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2011, 108(30):12325-30. (#Co-first author)
4. Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun. 2013; 4:1868. 
5. Liu B, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab. 2012;16(6):738-50. 
 
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